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Granulomatosis with Polyangiitis Treatment

Granulomatosis with polyangiitis (GPA, formerly called Wegener’s) is a rare disease of uncertain cause. It is the result of inflammation within the tissues called granulomatous inflammation and blood vessel inflammation ("vasculitis"), which can damage organ systems. The areas most commonly affected by GPA include the sinuses, lungs, and kidneys, but any site can be affected. Granulomatosis with polyangiitis (formerly called Wegener’s) is a rare disease of uncertain cause that can affect people of all ages. It is characterized by inflammation in various tissues, including blood vessels (vasculitis), but primarily in parts of the respiratory tract and the kidneys. Vasculitis is a general term that refers to inflammation of the blood vessels. When inflamed, the blood vessel may become weakened and stretch forming an aneurysm, or become so thin that it ruptures resulting in bleeding into the tissue. Vasculitis can also cause blood vessels to narrow to the point of closing off the vessel entirely. This can cause organs to become damaged from the loss of oxygen and nutrients that were being supplied by the blood.

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