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Eosinophilic Granulomatosis with Polyangiitis Treatment

Eosinophilic granulomatosis with polyangiitis (EGPA), formerly called Churg-Strauss syndrome, is a form of vasculitis a family of rare diseases characterized by inflammation of the blood vessels, which can restrict blood flow and damage vital organs and tissues. EGPA is one of the rarest forms of vasculitis and primarily affects the small blood vessels. Individuals diagnosed with EGPA usually have a history of asthma or allergies. The cause of EGPA is not fully understood by researchers. Vasculitis is classified as an autoimmune disorder a disease that occurs when the body’s natural defense system mistakenly attacks healthy tissues. Researchers believe an infection may set the inflammatory process in motion. Genetic and environmental factors, such as inhaled allergens, or certain medications or vaccinations, may also play a role in triggering an onset or relapse of EGPA. EGPA is traditionally treated with high-dose steroids such as prednisone, to reduce inflammation. For more severe cases, prednisone is used in combination with drugs that suppress the immune system’s response, such as methotrexate azathioprine, mycophenolate mofetil, and/or cytotoxic agents, such as cyclophosphamide. But long-term use of these drugs can put patients at risk for side effects, complications, and relapse.

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